Keeps getting better!
NepTunes is hands-down the best way to get iTunes to scrobble reliably, and the tight integration with iTunes and Spotify are top-notch. You can configure it to work silently as a Last.fm scrobbler or as a fully-featured controller that displays album artwork and controls your music from one place and anything in between. Plenty of options to make it work exactly as you need it to. This app is completely worth the cost of admission.
l33tpeas about
NepTunes for iTunes & Spotify, v1.43